5-(1,3-Benzothiazol-2-yl)pentanoic acid → Methyl 5-(1,3-benzothiazol-2-yl)pentanoate

HRID 478738ノート

反応式

HRID 478738 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15].Cl.[CH3:18]O>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][CH2:11][CH2:12][CH2:13][C:14]([O:16][CH3:18])=[O:15]

参加物

3

反応物 2

HCID 19714935-(1,3-Benzothiazol-2-yl)pentanoic acidHCID 21893726Hydrochloride methanol

生成物 1

HCID 18002644Methyl 5-(1,3-benzothiazol-2-yl)pentanoate収率 67%

実験手順

A solution of 5-(2-benzothiazolyl)pentanoic acid (1.54 g, 6.5 mmol, prepared according to the procedure of Example 12 in JP, A, 8-208631 (1996)) in hydrochloric acid-methanol (40 ml) was stirred at room temperature overnight, and evaporated. The residue was dissolved in chloroform, and washed with saturated aqueous sodium hydrogen carbonate. The organic layer was dried over anhydrous magnesium sulfate, evaporated, and purified through flash column chromatography to give methyl 5-(2-benzothiazolyl)pentanoate (1.08 g, 67%).

後処理

  1. customevaporated
  2. dissolutionThe residue was dissolved in chloroform
  3. washwashed with saturated aqueous sodium hydrogen carbonate
  4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  5. customevaporated
  6. custompurified through flash column chromatography

出典と根拠

ORDレコード
ord-6ea897a685174315ac633287610bf07e
出典データセット
uspto-grants-2003_11
特許番号
US06642250B2

反応ノート

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