化工社化工社 化学情報印刷レポート · 研究参考用
Ethanol → HCID 18003572、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Bromoacetic Acid | HCID 6227 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Ethyl isopropoxyacetate | HCID 537908 | — |
| 反応物 | (s)-2-But-3-enyloxy-3-(4-{2-[2-(4-isopropyl-phenyl)-5-methyl-oxazol-4-yl]-ethoxy}-benzo[b]thiophen-7-yl)-propionic acid | HCID 69556375 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | HCID 18003572 | HCID 18003572 | — |
反応手順
was prepared in analogy to example 39, but using in the aldol-coupling step ethyl isopropoxy-acetate instead of butyl butoxy-acetate as white crystals of mp. 148-150°. The former reagent was synthesized as described above for but-3-enyloxy-acetic acid (see example 65) from iPrOH, NaH, and bromo-acetic acid, followed by acid catalyzed esterification with EtOH.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06642389B2 |
| 出典データセット | uspto-grants-2003_11 |
| ORD ID | ord-1d3e39c5ea0a4de897ae8f9539fa04a3 |
| 出典メモ | uspto-grants-2003_11 |