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Phosphonium, (1,2-diethoxy-2-oxoethyl)triphenyl-, chloride (1:1) → 3-{3,5-dimethyl-4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2Z-ethoxy-acrylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphonium, (1,2-diethoxy-2-oxoethyl)triphenyl-, chloride (1:1) | HCID 11327835 | — |
| 反応物 | 3,5-Dimethyl-4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzaldehyde | HCID 18003604 | — |
| 反応物 | 3-{3,5-dimethyl-4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2Z-ethoxy-acrylic acid ethyl ester | HCID 69556024 | — |
| 生成物 | 3-{3,5-dimethyl-4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2Z-ethoxy-acrylic acid | HCID 69556636 | — |
反応手順
In analogy to the procedure described in example 120 f], 3-{3,5-dimethyl-4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2Z-ethoxy-acrylic acid ethyl ester {prepared from 3,5-dimethyl-4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzaldehyde (example 117) and (ethoxy-ethoxycarbonyl-methyl)-triphenyl-phosphonium chloride (K. K. Bach, H. R. El-Seedi, H. M. Jensen, H. B. Nielsen, I. Thomson, K. B. G. Torssell, Tetrahedron 1994, 50, 7543-7556) in analogy to the procedure described in example 114 c]} was saponified to yield 3-{3,5-dimethyl-4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2Z-ethoxy-acrylic acid as colorless crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06642389B2 |
| 出典データセット | uspto-grants-2003_11 |
| ORD ID | ord-b362b31a68d54496a120591d5e9e9028 |
| 出典メモ | uspto-grants-2003_11 |