Sotalol Hydrochloride → Sotalol

HRID 479264

反応式

HRID 479264 の反応式
[CH3:1][CH:2]([NH:4][CH2:5][CH:6]([OH:18])[C:7]1[CH:8]=[CH:9][C:10]([NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[CH:11][CH:12]=1)[CH3:3].Cl>O>[CH3:3][CH:2]([NH:4][CH2:5][CH:6]([OH:18])[C:7]1[CH:8]=[CH:9][C:10]([NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[CH:11][CH:12]=1)[CH3:1]

参加物

3

反応物 1

HCID 66245Sotalol Hydrochloride

生成物 1

HCID 5253Sotalol

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

Polyvinylpyrrolidone (500 g) is dissolved in about 25 kg water (or a mixture of water and alcohol) and 10 kg of sotalol hydrochloride is mixed therein to provide a sotalol/binder solution. In a fluidized bed coater, 10 kg of sugar spheres (20 to 50 mesh) are suspended in warm air and spray coated with the sotalol/binder solution until the seeds are uniformly coated with a desired amount of sotalol.

後処理

  1. additionis mixed

出典と根拠

ORDレコード
ord-a5e86ecfad164324903f52277f64ff44
出典データセット
uspto-grants-2003_11
特許番号
US06645524B2

関連ノート

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