関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | 1-(4-Chlorophenyl)-2-hydroxyethan-1-one | HCID 587085 | — |
| 反応物 | Potassium cyanate | HCID 11378442 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Diisopropyl Ether | HCID 7914 | — |
| 生成物 | 4-(4-Chlorophenyl)-2,3-dihydro-1,3-oxazol-2-one | HCID 11424125 | 85.1% |
反応手順
To a mixture of 4′-chloro-2-hydroxyacetophenone (3.41 g), potassium cyanate (3.25 g) and isopropanol (15 mL) was added dropwise acetic acid (2.88 g) at 50° C. The obtained mixture was stirred at 50° C. for 5 h and water (34 mL) was added. The precipitated crystals were collected by filtration, and washed with water and then with isopropyl ether to give 4-(4-chlorophenyl)-2-oxo-4-oxazoline (3.33 g; yield 85.1%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06699995B1 |
|---|
| 出典データセット | uspto-grants-2004_03 |
|---|
| ORD ID | ord-0c97421450554779ba21a39d6fa20d87 |
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| 出典メモ | uspto-grants-2004_03 |
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