Tetrabutylammonium Fluoride → HCID 57156543、化合物
反応式
[OH:1][C@H:2]1[CH2:34][CH2:33][C@@:32]2([CH3:35])[C:4](=[CH:5][CH2:6][C@@H:7]3[C@@H:31]2[CH2:30][CH2:29][C@@:28]2([CH3:36])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C@H:12]([CH3:27])[CH2:13][CH2:14][CH2:15][C@@H:16]([CH3:26])[CH2:17][O:18][Si](C(C)(C)C)(C)C)[C:3]1([CH3:38])[CH3:37].[F-].C([N+](CCCC)(CCCC)CCCC)CCC>CO>[CH3:38][C:3]1([CH3:37])[C@@H:2]([OH:1])[CH2:34][CH2:33][C@@:32]2([CH3:35])[C:4]1=[CH:5][CH2:6][C@@H:7]1[C@@H:31]2[CH2:30][CH2:29][C@@:28]2([CH3:36])[C@H:8]1[CH2:9][CH2:10][C@@H:11]2[C@H:12]([CH3:27])[CH2:13][CH2:14][CH2:15][C@@H:16]([CH3:26])[CH2:17][OH:18]参加物
4
実験手順
Silyl deprotection of 3β-hydroxy-4,4-dimethyl-(25R)-26-(tert-butyldimethylsilyloxy)cholest-5-ene (60 mg, 0.11 mmol) with tetrabutyl ammonium fluoride and recrystallisation from methanol to give 4,4-dimethyl-(25R)-cholest-5-ene-3β,26-diol (30 mg).