2-Bromo-4'-(trifluoromethyl)acetophenone → 2-Hydroxy-1-[4-(trifluoromethyl)phenyl]ethan-1-one

HRID 47932

反応式

HRID 47932 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=1)=[O:4].C([O-])=[O:16].[Na+]>CO>[OH:16][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=1)=[O:4]

参加物

4

反応物 2

HCID 3219792-Bromo-4'-(trifluoromethyl)acetophenoneHCID 2723810Sodium Formate

生成物 1

HCID 112871692-Hydroxy-1-[4-(trifluoromethyl)phenyl]ethan-1-one収率 80.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 2-bromo-4′-trifluoromethylacetophenone (40.0 g), sodium formate (40.0 g) and methanol (200 mL) was heated under reflux and stirred for 6 h. The reaction mixture was concentrated and poured into water (500 mL). The precipitated solid was collected by filtration, washed with water and air-dried to give the title compound as crystals (24.5 g, 80%). melting point: 112-114° C.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux
  3. concentrationThe reaction mixture was concentrated
  4. additionpoured into water (500 mL)
  5. filtrationThe precipitated solid was collected by filtration
  6. washwashed with water
  7. customair-dried

出典と根拠

ORDレコード
ord-4e10606f65fc4c4ab3290ea0ed22b311
出典データセット
uspto-grants-2004_03
特許番号
US06699995B1

関連ノート

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