化工社化工社 化学情報印刷レポート · 研究参考用
(R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-phenylpentanoic acid → (2R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-cyclohexylpentanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-phenylpentanoic acid | HCID 10803584 | — |
| 触媒 | Rhodium | HCID 23948 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (2R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-cyclohexylpentanoic acid | HCID 9835906 | 89.4% |
反応手順
A solution of (R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-phenylpentanoic acid (2.2 g, 7.5 mmol) and 5%Rh/C (0.22 g) in methanol (220 ml) was stirred at room temperature, under hydrogen (150 p.s.i.) for 24 hours and then filtered through celite. The filtrate was concentrated in vacuo to leave the title compound as an oil (2.0 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06645993B2 |
| 出典データセット | uspto-grants-2003_11 |
| ORD ID | ord-cc5272357d0a4327898538824ebdcb1d |
| 出典メモ | uspto-grants-2003_11 |