Ethanol → Ethyl 6-Aminonicotinate

HRID 479733

反応式

HRID 479733 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[CH2:11](O)[CH3:12]>>[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH2:11][CH3:12])=[O:7])=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 702EthanolHCID 184966-Aminonicotinic acid

生成物 1

HCID 235927Ethyl 6-Aminonicotinate

実験手順

To a suspension of 1.3 g (9.4 mmol) 6-aminonicotinic acid in 100 mL of ethanol, was bubbled in dry hydrochloric acid at 0° C., then the solution was refluxed until all the solids dissolved. The solvents were removed under reduced pressure, the residue dissolved in ethyl acetate, washed with saturated sodium bicarbonate, brine and concentrated to afford 1.37 g of a white solid, m/e=166(M+H).

後処理

  1. customwas bubbled in dry hydrochloric acid at 0° C.
  2. temperaturethe solution was refluxed until all the solids
  3. dissolutiondissolved
  4. customThe solvents were removed under reduced pressure
  5. dissolutionthe residue dissolved in ethyl acetate
  6. washwashed with saturated sodium bicarbonate, brine
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-16a0a4e9bd2244cdb60a968f4ae8997f
出典データセット
uspto-grants-2003_11
特許番号
US06646010B2

関連ノート

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