Phosphorus pentachloride → (4-Fluoro-3-phenoxyphenyl)methanesulfonyl chloride
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][S:9]([O-])(=[O:11])=[O:10])=[CH:4][C:3]=1[O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[Na+].P(Cl)(Cl)(Cl)(Cl)[Cl:22]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][S:9]([Cl:22])(=[O:11])=[O:10])=[CH:4][C:3]=1[O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1参加物
3
実験手順
The sodium sulfonate obtained in step 1 is mixed with phosphorous pentachloride at room temperature for two days. An ice-water mixture is added and the aqueous solution is extracted with methylene chloride. The organic extract is washed with water, dried over anhydrous sodium sulfate, and concentrated in vacuo to obtain (4-fluoro-3-phenoxyphenyl)methanesulfonyl chloride as a syrup (2.05 g).
後処理
- extractionthe aqueous solution is extracted with methylene chloride
- extractionThe organic extract
- washis washed with water
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-06dc0694242f41569ec45c17784ef03d
- 出典データセット
- uspto-grants-2003_11
- 特許番号
- US06646166B1
反応ノート
読み込み中…