Procainamide → 4-Anilino-5-bromo-2-{4-{N-[2-(diethylamino)ethyl]carbamoyl}anilino}pyrimidine
反応式
[CH2:1]([N:3]([CH2:16][CH3:17])[CH2:4][CH2:5][NH:6][C:7]([C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[CH:11][CH:10]=1)=[O:8])[CH3:2].[NH:18]([C:25]1[C:30]([Br:31])=[CH:29][N:28]=[C:27](Cl)[N:26]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[NH:18]([C:25]1[C:30]([Br:31])=[CH:29][N:28]=[C:27]([NH:13][C:12]2[CH:11]=[CH:10][C:9]([C:7](=[O:8])[NH:6][CH2:5][CH2:4][N:3]([CH2:1][CH3:2])[CH2:16][CH3:17])=[CH:15][CH:14]=2)[N:26]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1参加物
3
実験手順
Using an analogous method to that described in Example 103, but starting from 4-{N-[2-(diethylamino)ethyl]carbamoyl}aniline and 4-anilino-5-bromo-2-chloropyrimidine (Method 15), the product was obtained. NMR: 1.0 (t, 6H), 2.4 (m, 4H), 3.3 (m, 4H) 7.2 (t, 1H), 7.4 (t, 2H), 7.6 (t, 6H), 8.1 (bs, 1H), 8.2 (s, 1H), 8.7 (s, 1H), 9.6 (s, 1H); MS (MH+): 483, 485.
後処理
- customthe product was obtained
出典と根拠
- ORDレコード
- ord-8dddd4bf727a4144b4cf883792ddd8c9