Acetone → 4-Amino-2-chlorobenzoic acid

HRID 48006

反応式

HRID 48006 の反応式
[Cl:1][C:2]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[H][H].CC(C)=O>C(O)C.[C].[Pd]>[NH2:11][C:9]1[CH:8]=[CH:7][C:3]([C:4]([OH:6])=[O:5])=[C:2]([Cl:1])[CH:10]=1

参加物

6

反応物 3

HCID 180AcetoneHCID 74482-Chloro-4-nitrobenzoic acidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 171544-Amino-2-chlorobenzoic acid

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

In ethanol (250 mL) was dissolved 100 g (F.W. 201.57, 496 mmol) of 2-chloro-4-nitrobenzoic acid (1) and after replacing with argon, a 10% palladium carbon catalyst (4.0+1.5 g) was added thereto. After replacing with hydrogen, the mixture was stirred at room temperature for 72 hours. The formed crystal was dissolved with acetone and filtered to remove the catalyst. The solvent was distilled under reduced pressure to quantitatively obtain 88 g of the target 4-amino-2-chlorobenzoic acid (2).

後処理

  1. filtrationfiltered
  2. customto remove the catalyst
  3. distillationThe solvent was distilled under reduced pressure to quantitatively obtain 88 g of the target 4-amino-2-chlorobenzoic acid (2)

出典と根拠

ORDレコード
ord-1a0fb14af5eb4c08bc790f0d9076e4d8
出典データセット
uspto-grants-2004_03
特許番号
US06700013B2

関連ノート

読み込み中…