Hydrochloric Acid → 4-(Cyclopropylcarbonyl)benzeneacetic acid

HRID 48016

反応式

HRID 48016 の反応式
Cl[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14](N(OC)C)=[O:15])=[CH:9][CH:8]=1)=[O:6].[OH-:20].[K+].Cl>C(O)C>[CH:4]1([C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH2:13][C:14]([OH:15])=[O:20])=[CH:11][CH:12]=2)=[O:6])[CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 9857023[4-(4-Chloro-1-oxobutyl)]-N-methoxy-N-methyl benzeneacetamide

生成物 1

HCID 1937314-(Cyclopropylcarbonyl)benzeneacetic acid収率 95%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Add purified [4-(4-chloro-1-oxobutyl)]-N-methoxy-N-methyl-benzeneacetamide (9.4 g, 330 mmol) to a solution of potassium hydroxide (22.0 g) in ethanol (160 mL). Stir 18 hours. Pour the solution into dilute hydrochloric acid (30 mL of concentrated hydrochloric acid in 500 mL of water). Extract the solution with three 500-mL portions of ethyl acetate. Dry the combined organic phases over anhydrous magnesium sulfate and concentrate to give the title compound (6.4 g, 95%).

後処理

  1. additionAdd
  2. extractionExtract the solution with three 500-mL portions of ethyl acetate
  3. dry with materialDry the combined organic phases over anhydrous magnesium sulfate
  4. concentrationconcentrate

出典と根拠

ORDレコード
ord-f53ba3c5e8524a56b25ef814a2ac2587
出典データセット
uspto-grants-2004_03
特許番号
US06700012B2

関連ノート

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