Hydrochloric Acid → Methyl 4-(2-aminoethoxy)benzoate

HRID 480302

反応式

HRID 480302 の反応式
[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][NH:13]C(=O)C(C)(C)C)=[CH:6][CH:5]=1.Cl>CCO>[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:5]=[CH:6][C:7]([O:10][CH2:11][CH2:12][NH2:13])=[CH:8][CH:9]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 538869664-[2-(2,2-Dimethyl-propionylamino)ethoxy]-benzoic acid methyl ester

生成物 1

HCID 14097616Methyl 4-(2-aminoethoxy)benzoate収率 108.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 4-[2-(2,2-dimethyl-propionylamino)-ethoxy]-benzoic acid methyl ester (350 mg) in EtOH (6 mL) at 0° C. was added concentrated HCl (3 mL). The solution was warmed to room temperature and was concentrated in vacuo to provide the hydrochloride salt of 4-(2-amino-ethoxy)-benzoic acid methyl ester (266 mg) as a white solid which was used in the next step without further purification.

後処理

  1. concentrationwas concentrated in vacuo

出典と根拠

ORDレコード
ord-86bf8b63bc1344aebbc700c1154023bc
出典データセット
uspto-grants-2003_11
特許番号
US06649657B2

関連ノート

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