ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Triethylamine → Methanesulphonic Acid 1-{4-[1-(4-cyclohex-1-enyl-phenyl)-3-(3,5-dichlorophenyl)-ureidomethyl]phenyl}-2-(2H-tetrazol-5-yl)ethyl Ester

HRID 480384
ノート
印刷プレビュー

反応式

HRID 480384 の反応式
[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([N:13]([CH2:25][C:26]3[CH:31]=[CH:30][C:29]([CH:32]([OH:39])[CH2:33][C:34]4[N:35]=[N:36][NH:37][N:38]=4)=[CH:28][CH:27]=3)[C:14]([NH:16][C:17]3[CH:22]=[C:21]([Cl:23])[CH:20]=[C:19]([Cl:24])[CH:18]=3)=[O:15])=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1.C(N(CC)CC)C.[CH3:47][S:48](Cl)(=[O:50])=[O:49].N12CCCN=C1CCCCC2>C(Cl)Cl>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([N:13]([CH2:25][C:26]3[CH:27]=[CH:28][C:29]([CH:32]([O:39][S:48]([CH3:47])(=[O:50])=[O:49])[CH2:33][C:34]4[N:35]=[N:36][NH:37][N:38]=4)=[CH:30][CH:31]=3)[C:14]([NH:16][C:17]3[CH:22]=[C:21]([Cl:23])[CH:20]=[C:19]([Cl:24])[CH:18]=3)=[O:15])=[CH:11][CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 187689131-(4-Cyclohex-1-enylphenyl)-3-(3,5-dichlorophenyl)-1-{4-[1-hydroxy-2-(2H-tetrazol-5-yl)ethyl]benzyl}urea

生成物 1

HCID 20601515Methanesulphonic Acid 1-{4-[1-(4-cyclohex-1-enyl-phenyl)-3-(3,5-dichlorophenyl)-ureidomethyl]phenyl}-2-(2H-tetrazol-5-yl)ethyl Ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
0 °C

実験手順

1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dichlorophenyl)-1-{4-[1-hydroxy-2-(2H-tetrazol-5-yl)ethyl]benzyl}urea (100 mg, 0.17 mmol) was dissolved in DCM (1 ml) and triethyl amine (27 μl, 0.195 mmol) was added. The mixture was cooled to 0° C. and methansulphonyl chloride (15 μl, 0.195 mmol) was added followed by 1,8-diazabicyclo[5,4,0]-undec-7-ene (29 μl, 0.195 mmol). The mixture was stirred at 0° C. for 2 hours, and at room temperature overnight, then diluted with DCM (20 ml) and washed with brine (20 ml). The organic solution was dried with anhydrous sodium sulphate and evaporated to dryness, to give pure title material as a white powder. Yield: 113 mg (100%).

後処理

  1. washwashed with brine (20 ml)
  2. dry with materialThe organic solution was dried with anhydrous sodium sulphate
  3. customevaporated to dryness
  4. customto give pure title material as a white powder

出典と根拠

ORDレコード
ord-2c201c30739b448985d5226253ec6593
出典データセット
uspto-grants-2003_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06649641B2

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート