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Hydrochloric Acid → 2-Amino-4-phenylamino-6-methylpyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Aniline | HCID 6115 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 2-Amino-4-chloro-6-methylpyrimidine | HCID 21810 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Amino-4-phenylamino-6-methylpyrimidine | HCID 608203 | 34.5% |
反応手順
Compound No. 45. (CNI-4594) A mixture of aniline (0.93 g) and 2-amino-4-chloro-6-methylpyrimidine (1.44 g) in 36 mL water was treated with 0.84 mL conc HCl and heated at reflux for 1 hr. Addition of 20 mL 1N KOH gave a light buff solid, which was filtered out, dried, and recrystallized from ethyl acetate/2-methoxyethanol and ethyl acetate/hexane to give 0.69 g 4-phenylamino-2-amino-6-methylpyrimidine, mp 179-180° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06649797B2 |
| 出典データセット | uspto-grants-2003_11 |
| ORD ID | ord-6b41bcf745214136b70b90502142cde3 |
| 出典メモ | uspto-grants-2003_11 |