関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 1H-Pyrazol-3-amine, 5-methyl- | HCID 93146 | — |
| 反応物 | 4,6-Dichloro-2[[(4-methoxyphenyl)methyl]thio]pyrimidine | HCID 13413724 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | [6-chloro-2-(4-methoxy-benzylsulfanyl)-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine | HCID 178419077 | — |
反応手順
To a solution of above-prepared 4,6-dichloro-2-(4-methoxy-benzylsulfanyl)-pyrimidine (915 mg, 3.04 mmol) and 3-amino-5-methylpyrazole (310 mg, 3.19 mmol) in BuOH (20 mL) is added diisopropylethylamine (0.56 mL, 3.19 mmol) followed by sodium iodide (455 mg, 3.04 mmol). The reaction mixture is stirred for 15 hours at 120° C. The solvent is removed in vacuo and the residue is purified by flash chromatography (SiO2, hexane/AcOEt gradient) to give [6-chloro-2-(4-methoxy-benzylsulfanyl)-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06653300B2 |
|---|
| 出典データセット | uspto-grants-2003_11 |
|---|
| ORD ID | ord-a963d47eb7884ecbb6832fc6d11cb7fa |
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| 出典メモ | uspto-grants-2003_11 |
|---|
