関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | 4,6-Dichloro-2-(methylthio)pyrimidine | HCID 80531 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 1H-Pyrazol-3-amine, 5-methyl- | HCID 93146 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | HCID 178418729 | HCID 178418729 | — |
反応手順
To a solution of 4,6-dichloro-2-methylsulfanyl-pyrimidine (5 g, 25.6 mmol) and 3-amino-5-methylpyrazole 2.61 g, 26.9 mmol) in BuOH (60 mL) is added diisopropylethylamine (4.69 mL, 26.9 mmol) followed by sodium iodide (3.84 g, 25.6 mmol). The reaction mixture is stirred for 15 hours at 120° C. The solvent is then removed in vacuo and the residue is purified by flash chromatography (SiO2, hexane/AcOEt gradient) to give [6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06653300B2 |
|---|
| 出典データセット | uspto-grants-2003_11 |
|---|
| ORD ID | ord-fcfe211651cd4a3ca6bee7fae9b39959 |
|---|
| 出典メモ | uspto-grants-2003_11 |
|---|
