3-Bromoaniline → 3-[(3-Bromophenyl)amino]-1,1,1-trifluoro2-propanol

HRID 48066

反応式

HRID 48066 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[F:9][C:10]([F:15])([F:14])[CH:11]1[O:13][CH2:12]1>>[Br:1][C:2]1[CH:3]=[C:4]([NH:5][CH2:12][CH:11]([OH:13])[C:10]([F:15])([F:14])[F:9])[CH:6]=[CH:7][CH:8]=1

参加物

3

反応物 2

HCID 115623-BromoanilineHCID 5207692-(Trifluoromethyl)oxirane

生成物 1

HCID 235061023-[(3-Bromophenyl)amino]-1,1,1-trifluoro2-propanol収率 84%

反応条件

温度
70 °C

実験手順

Ex-633A) 3-Bromoaniline (2.15 g, 12.5 mmol) and 1,1,1-trifluoro-2,3-epoxypropane (1.0 g, 8.9 mmol) were placed in a sealed vial, heated to 70° C. and stirred for 1 h under an atmosphere of nitrogen. The crude product was purified by flash column chromatography on silica gel eluting with CH2CH2:hexane (2:1) to give 2.11 g (84%) of the desired 3-[(3-bromophenyl)amino]-1,1,1-trifluoro-2-propanol product as a light amber oil, 98% pure by HPLC analysis. MS m/z=284/286 [M+H]+.

後処理

  1. customThe crude product was purified by flash column chromatography on silica gel eluting with CH2CH2:hexane (2:1)

出典と根拠

ORDレコード
ord-95a93c4cf6c848f2a9926d190087c059
出典データセット
uspto-grants-2004_03
特許番号
US06699898B2

関連ノート

読み込み中…