Methanol → Methyl L-ornithine monohydrochloride

Into a stirred suspension of L-(+)-ornithine hydrochloride (Aldrich) in methanol was bubbled anhydrous hydrochloric acid gas until the solution was saturated. The reaction mixture was capped with a rubber septum and stirring was continued overnight at room temperature. The solvent was then stripped under reduced pressure and the residue triturated with ether. The resulting solid was dried under reduced pressure to afford L-(+)-ornithine methyl ester hydrochloride as a white solid (97% yield).

1. customwas bubbled anhydrous hydrochloric acid gas until the solution
2. customThe reaction mixture was capped with a rubber septum
3. customthe residue triturated with ether
4. customThe resulting solid was dried under reduced pressure

ORDレコード

ord-969ab8a01746414fa7adc2f26c944ffb

出典データセット

uspto-grants-2003_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06653303B1