2,5-Difluorophenylacetic acid → N-[(2,5-difluorophenyl)acetyl]aIanine iso-butyl ester

HRID 480909ノート

反応式

HRID 480909 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH2:9][C:10]([OH:12])=O.[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH2:20])[CH:14]([CH3:16])[CH3:15]>>[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH:20][C:10](=[O:12])[CH2:9][C:3]1[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=1[F:1])[CH:14]([CH3:16])[CH3:15]

参加物

3

反応物 2

HCID 5228232,5-Difluorophenylacetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

生成物 1

HCID 22894969N-[(2,5-difluorophenyl)acetyl]aIanine iso-butyl ester

実験手順

Following General Procedure BI above, and using 2,5-difluorophenylacetic acid (Aldrich) and alanine iso-butyl ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

後処理

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

出典と根拠

ORDレコード
ord-efa75f00297747a0b7d8f665ce4af3d2
出典データセット
uspto-grants-2003_11
特許番号
US06653303B1

反応ノート

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