3-Nitrophenylacetic acid → N-[(3-nitrophenyl)acetyl]-alanine iso-butyl ester

HRID 480913

反応式

HRID 480913 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]([OH:13])=O)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].Cl.[CH2:15]([O:19][C:20](=[O:24])[C@H:21]([CH3:23])[NH2:22])[CH:16]([CH3:18])[CH3:17]>>[CH2:15]([O:19][C:20](=[O:24])[C@H:21]([CH3:23])[NH:22][C:11](=[O:13])[CH2:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)[CH:16]([CH3:18])[CH3:17]

参加物

3

反応物 2

HCID 158763-Nitrophenylacetic acidHCID 865849812-Methylpropyl (2S)-2-aminopropanoate hydrochloride

生成物 1

HCID 54157293N-[(3-nitrophenyl)acetyl]-alanine iso-butyl ester

実験手順

Following General Procedure BH above and using 3-nitrophenylacetic acid (Aldrich) and L-alanine iso-Butyl Ester hydrochloride (from Example BB above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by recrystallization from butyl chloride.

後処理

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. customwas by recrystallization from butyl chloride

出典と根拠

ORDレコード
ord-34593f47c1094e638d3f9d765e06d2ee
出典データセット
uspto-grants-2003_11
特許番号
US06653303B1

関連ノート

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