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L-Alanine ethyl ester → N-[(3,5difluorophenyl)acetyl]alanine Ethyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-Alanine ethyl ester | HCID 76507 | — |
| 反応物 | 3,5-Difluorophenylacetic acid | HCID 145424 | — |
| 生成物 | N-[(3,5difluorophenyl)acetyl]alanine Ethyl Ester | HCID 54306296 | — |
反応手順
Following General Procedure BG and using 3,5-difluorophenylacetic acid (Aldrich) and alanine ethyl ester (Aldrich), the title compound was prepared as a solid with a melting point of 93°-95° C. The reaction was monitored by tlc on silica gel (Rf=0.8 in EtOAC) and purification was by chromatography on silica gel using EtOAc as the eluant followed by recrystallization from 1-chlorobutane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06653303B1 |
| 出典データセット | uspto-grants-2003_11 |
| ORD ID | ord-792d006ee6db4b4b93331f89edad15e1 |
| 出典メモ | uspto-grants-2003_11 |