関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Sodium Chloride | HCID 5234 | — |
| 反応物 | Salbutamol Sulfate | HCID 9884233 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Salbutamol | HCID 2083 | — |
反応手順
In an alternative embodiment, the inhalation solution of the present invention may be prepared as follows: (i) fitting a high density polyethylene (HDPE) or stainless steel formulation tank with a bottom drain and peristaltic recirculation system (for HDPE) or tri-blender (for stainless steel) for mixing; (ii) filling the tank with approximately 90% of the required amount of Purified Water USP at a temperature of between 18° C. to 25° C.; while mixing, (iii) adding sulfuric acid, Sodium Chloride USP, and at least a therapeutically effective pediatric amount of Albuterol Sulfate USP to the tank; (iv) continue mixing until all chemical components are dissolved; (v) adding Purified Water USP to adjust the final volume, if necessary, thus producing an albuterol mixture.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06702997B2 |
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| 出典データセット | uspto-grants-2004_03 |
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| ORD ID | ord-5e22ad9c5cce42a49be1bce2ca1f9a58 |
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| 出典メモ | uspto-grants-2004_03 |
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