Aniline → Methyl 3-anilino-5-bromobenzoate
反応式
COC(=O)c1cc(Br)cc(Br)c1.Nc1ccccc1>CC(=O)O.CC(=O)O.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.Cc1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd]>COC(=O)c1cc(Br)cc(Nc2ccccc2)c1参加物
7
反応条件
- 温度
- 110 °C
実験手順
aniline (0.380 g, 4.08 mmol), methyl 3,5-dibromobenzoate (1.000 g, 3.40 mmol), Pd(OAc)2 (0.076 g, 0.34 mmol), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (0.295 g, 0.51 mmol) and CESIUM CARBONATE (1.663 g, 5.10 mmol) were stirred in toluene (10 mL) and degassed with nitrogen for 15 minutes. The mixture was then heated at 110 °C under nitrogen for 24 hours. No evidence of any significant amount of product (ester or acid) therfore abandaned.
出典と根拠
- ORDレコード
- ord-c6d710180f5249588ab02dc546a2ae67
- 出典データセット
- 750 AstraZeneca ELN dataset
- 元リンク
- 出典を表示
反応ノート
読み込み中…