Hydrazine, acetate (1:1) → HCID 178469869、化合物

HRID 481085

反応式

HRID 481085 の反応式
[CH2:1]([O:3][C:4]([C:6]1[C:7]2[C:15](=O)[C:14](=[CH:17][N:18](C)C)[CH2:13][CH2:12][CH2:11][C:8]=2[NH:9][CH:10]=1)=[O:5])[CH3:2].C(O)(=O)C.[NH2:25]N>>[CH2:1]([O:3][C:4]([C:6]1[C:7]2[C:15]3=[N:25][NH:18][CH:17]=[C:14]3[CH2:13][CH2:12][CH2:11][C:8]=2[NH:9][CH:10]=1)=[O:5])[CH3:2]

参加物

3

反応物 2

HCID 165591Hydrazine, acetate (1:1)HCID 590720525-Dimethylaminomethylene-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta[b]pyrrole-3-carboxylic acid ethyl ester

生成物 1

HCID 178469869HCID 178469869、化合物

実験手順

The title compound is prepared in analogous fashion to Example 8 using 5-dimethylaminomethylene-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta[b]pyrrole-3-carboxylic acid ethyl ester and hydrazine acetate. The crude product mixture is carried into the next step without purification. Electrospray mass spectrum: m/z 246 [M+1]; 1H NMR (DMSO-d6, 300 MHz) δ>13.0 (br s, 1H), 11.65 (br s, 1H), 7.49 (s, 1H), 7.20 (s, 1H), 4.25 (q, J=7.2 Hz, 2H), 2.91 (m, 2H), 2.76 (m, 2H), 1.84 (m, 2H) 1.28 (t, J=7.2 Hz, 3H).

後処理

  1. customThe crude product mixture is carried into the next step without purification

出典と根拠

ORDレコード
ord-806f9550f9e74a94ae327d9783763176
出典データセット
uspto-grants-2003_11
特許番号
US06653471B2

関連ノート

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