Potassium Dichromate → 3'-METHOXY-3-PHENYLPROPIOPHENONE

HRID 481162ノート

反応式

HRID 481162 の反応式
[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.[K+].[K+].[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:20]([OH:29])[CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:17]=[CH:18][CH:19]=1>O.S(=O)(=O)(O)O.CCOCC>[CH3:12][O:13][C:14]1[CH:15]=[C:16]([C:20](=[O:29])[CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:17]=[CH:18][CH:19]=1

参加物

6

反応物 2

HCID 24502Potassium DichromateHCID 15524231HCID 15524231、化合物

生成物 1

HCID 112071953'-METHOXY-3-PHENYLPROPIOPHENONE収率 83.2%

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 1118Sulfuric Acid溶媒HCID 3283Diethyl Ether溶媒

反応条件

温度
20 °C

実験手順

14.9 g (0.05 mole) of potassium dichromate in a mixture of 50 ml of water and 10 ml of concentrated sulfuric acid were added to a solution of 34 g (0.14 mole) of 1-(3-methoxyphenyl)-3-phenylpropan-1-ol in 500 ml of ether while cooling with ice and stirred overnight at 20° C. The aqueous, green phase was separated and extracted twice with 100 ml of ether each time. The combined ether extracts were dried over sodium sulfate and the solvent was then removed in vacuo. 28.0 g (83%) of the compound 1-(methoxyphenyl)-3-phenylpropan-1-one were obtained as a yellow oil, which was reacted further without prior purification.

後処理

  1. temperaturewhile cooling with ice
  2. customThe aqueous, green phase was separated
  3. extractionextracted twice with 100 ml of ether each time
  4. dry with materialThe combined ether extracts were dried over sodium sulfate
  5. customthe solvent was then removed in vacuo

出典と根拠

ORDレコード
ord-592d635826f04e7fb005ac5fb930fe88
出典データセット
uspto-grants-2003_11
特許番号
US06653508B2

反応ノート

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