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3-Methoxybenzaldehyde → (2RS)-2-benzyl-1-(2,5-dichlorophenyl)-3-dimethylaminopropan-1-one hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Methoxybenzaldehyde | HCID 11569 | — |
| 反応物 | 2,5-Dichlorobenzaldehyde | HCID 80702 | — |
| 反応物 | (2RS)-2-benzyl-1-(2,4-dichlorophenyl)-3-dimethylaminopropan-1-one hydrochloride | HCID 18767270 | — |
| 生成物 | (2RS)-2-benzyl-1-(2,5-dichlorophenyl)-3-dimethylaminopropan-1-one hydrochloride | HCID 18767286 | — |
反応手順
The synthesis was carried out according to the procedure of Example 1, except that 5.0 g (0.028 mole) of 2,5-dichlorobenzaldehyde were used instead of 3-methoxybenzaldehyde. The reaction steps involving Grignard reaction, oxidation and Mannich reaction led to a total yield of 1.4 g (14%) of (2RS)-2-benzyl-1-(2,4-dichlorophenyl)-3-dimethylaminopropan-1-one hydrochloride with a melting point of 140° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06653508B2 |
| 出典データセット | uspto-grants-2003_11 |
| ORD ID | ord-207ef4f9f5a64ae1989bb39099596136 |
| 出典メモ | uspto-grants-2003_11 |