Lipoamide → Diglycerol 1,2-distearate

HRID 481270

反応式

HRID 481270 の反応式
C1C(CCCCC(N)=O)SSC1.C(O)C(O)C[O:16][CH2:17][CH:18]([OH:21])[CH2:19][OH:20].[C:24]([OH:43])(=[O:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]>OCC(CO)O>[C:24]([OH:43])(=[O:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41].[C:24]([OH:43])(=[O:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41].[OH:16][CH2:17][CH:18]([CH2:19][OH:20])[OH:21].[OH:16][CH2:17][CH:18]([CH2:19][OH:20])[OH:21]

参加物

5

反応物 3

HCID 863LipoamideHCID 5281Stearic AcidHCID 42953Diglycerin

生成物 1

HCID 131720779Diglycerol 1,2-distearate収率 5%

試薬・触媒・溶媒 1

HCID 753Glycerol溶媒

反応条件

温度
70 °C

実験手順

heating to 70°C. Thereto were added 10 parts by weight of an immobilized lipase preparation (trade name: Lipozyme, IM20, mfd. by NOVO) composed of a lipase originating from Mucor miehei immobilized on an anion exchange resin and 29 parts by weight of linear diglycerol. Then the stearic acid was reacted with the linear glycerol under reduced pressure (2 torr) at 70° C. for 4 hours. The reaction product was filtered to eliminate the immobilized enzyme. The obtained filtrate was put in a continuous thin film distilling apparatus and distillation was carried out to eliminate unreacted stearic acid and diglycerol, and monoesters. The liquid thus obtained was subjected to silica gel column chromatography to eliminate triesters, thereby giving a diglycerol distearate mixture comprising diglycerol 1,6-distearate (about 50%), diglycerol 1,5-distearate (about 45%) and diglycerol 2,5-distearate (about 5%).

後処理

  1. additionThereto were added 10 parts
  2. filtrationThe reaction product was filtered
  3. distillationdistilling
  4. distillationapparatus and distillation
  5. customThe liquid thus obtained

出典と根拠

ORDレコード
ord-a93092b2ff014c83bfa5ca7786229ba5
出典データセット
uspto-grants-1998_08
特許番号
US05789011

関連ノート

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