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Triethylamine → Methyl 4-[(4-diphenylmethyl-1-piperazinyl)methyl]phenylacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Benzhydrylpiperazine | HCID 70048 | — |
| 反応物 | Methyl 2-(4-(bromomethyl)phenyl)acetate | HCID 11770640 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Methyl 4-[(4-diphenylmethyl-1-piperazinyl)methyl]phenylacetate | HCID 10993378 | 90.8% |
反応手順
A 200 ml eggplant-shaped flask was charged with 5.38 g of methyl 4-bromomethylphenylacetate, 6.06 g of 1-benzhydrylpiperazine, 6.1 ml of triethylamine, and 100 ml of dioxane and the mixture was stirred at room temperature for 5 hours. The solvent was then distilled off and the residue was extracted with ethyl acetate. The extract was washed with water, the solvent was distilled off, and the residue was recrystallized from methanol to provide 8.33 g of methyl 4-[(4-diphenylmethyl-1-piperazinyl)methyl]phenylacetate melting at 124° C.-125° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05789409 |
| 出典データセット | uspto-grants-1998_08 |
| ORD ID | ord-89b68ced720c466195934876f641ea89 |
| 出典メモ | uspto-grants-1998_08 |