4-Toluenesulfonyl chloride → HCID 67620835、化合物

HRID 481312ノート

反応式

HRID 481312 の反応式
[CH2:1]([O:8][C:9]([C:11]1[CH:12]=[N+:13]([O-])[CH:14]=[CH:15][C:16]=1[CH3:17])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(C)C=CC(S([Cl:28])(=O)=O)=CC=1>O1CCOCC1>[ClH:28].[CH2:1]([O:8][C:9]([C:11]1[CH:12]=[N:13][CH:14]=[CH:15][C:16]=1[CH2:17][Cl:28])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 73974-Toluenesulfonyl chlorideHCID 53818160HCID 53818160、化合物

生成物 1

HCID 67620835HCID 67620835、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture of the title compound of Preparation 7 (1.8 g, 7.3 mmol), p-toluenesulfonylchloride (2.0 g, 11 mmol) and dioxane (10 ml) was heated under reflux for 1.5 hours. The reaction mixutre was cooled to 0° C., diluted with water, treated with solid NaHCO3 and extracted with diethyl ether. The ether extracts were combined, dried (Na2 SO4), filtered and treated with HCl gas. The precipitate was filtered and washed with diethyl ether to afford 1.4 g of the title compound of this preparation. mp 149°-151° C. 1H NMR (CDCl3): δ 5.27 (2H, s), 5.42 (2H, s), 7.32-7.39 (5H, m), 8.35 (1H, d, J=6), 8.91 (1H, d, J=6), 9.28 (1H, s).

出典と根拠

ORDレコード
ord-bd0ae2341e5c4d298a4fdb2a25dbb2fc
出典データセット
uspto-grants-1998_08
特許番号
US05789408

反応ノート

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