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Chloroacetyl chloride → 2-Chloro-1-[4-(2-cyanophenyl)piperazin-1-yl]ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroacetyl chloride | HCID 6577 | — |
| 反応物 | Calcium Carbonate | HCID 10112 | — |
| 反応物 | N-(2-Cyanophenyl)piperazine | HCID 2735875 | — |
| 反応物 | 2-Chloro-1-(4-o-tolylpiperazin-1-yl)ethanone | HCID 4741212 | — |
| 溶媒 | Methyl Ethyl Ketone | HCID 6569 | — |
| 生成物 | 2-Chloro-1-[4-(2-cyanophenyl)piperazin-1-yl]ethanone | HCID 10400554 | — |
反応手順
Compound 17A is prepared according to the same procedure as that for 12A, using the following reactants: chloroacetyl chloride (670 μl, 8.4 mmol), 1-(2-cyanophenyl)piperazine (1.32 g, 7 mmol), calcium carbonate (2.1 g, 21 mmol), methyl ethyl ketone (30 ml).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05789412 |
| 出典データセット | uspto-grants-1998_08 |
| ORD ID | ord-ba90fcc583e242a0a902eaec2bc6b1ed |
| 出典メモ | uspto-grants-1998_08 |