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Chloroacetyl chloride → 2-Chloro-1-(4-mesitylpiperazin-1-yl)ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroacetyl chloride | HCID 6577 | — |
| 反応物 | Calcium Carbonate | HCID 10112 | — |
| 反応物 | 1-(2,4,6-Trimethylphenyl)piperazine | HCID 2760822 | — |
| 反応物 | 2-Chloro-1-(4-o-tolylpiperazin-1-yl)ethanone | HCID 4741212 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Methyl Ethyl Ketone | HCID 6569 | — |
| 生成物 | 2-Chloro-1-(4-mesitylpiperazin-1-yl)ethanone | HCID 4741171 | 96% |
反応手順
Compound 52A is prepared according to the procedure described for compound 12A, using the following reactants: chloroacetyl chloride (480 ml, 6.05 mmol); 1-(2,4,6-trimethylphenyl)piperazine (31A) (1.122 g, 5.5 mmol); calcium carbonate (1.65 g, 16.5 mmol); methyl ethyl ketone (25 ml) and dimethylformamide (10 ml) to solubilize the 1-(2,4,6-trimethylphenyl)piperazine).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05789412 |
| 出典データセット | uspto-grants-1998_08 |
| ORD ID | ord-f46ed88c3d404a2da382d30644ae8c66 |
| 出典メモ | uspto-grants-1998_08 |