Hydroxyphenylacetic acid → Benzeneacetic acid, 4-hydroxy-, methyl ester

HRID 48146

反応式

HRID 48146 の反応式
Cl.[OH:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.[CH3:13]O>>[CH3:13][O:11][C:10](=[O:12])[CH2:9][C:6]1[CH:5]=[CH:4][C:3]([OH:2])=[CH:8][CH:7]=1

参加物

4

反応物 3

HCID 127Hydroxyphenylacetic acidHCID 313Hydrochloric AcidHCID 887Methanol

生成物 1

HCID 518900Benzeneacetic acid, 4-hydroxy-, methyl ester

実験手順

Hydrogen chloride was bubbled through a solution of (4-hydroxyphenyl) acetic acid (25 g, 0.16 mole) in methanol (100 ml) at room temperature. An exotherm resulted in the solution refluxing for about 10 minutes. The mixture was allowed to cool to room temperature and the solvent was evaporated in vacuo to afford methyl(4-hydroxyphenyl)acetate as a yellow oil (27.5 g) which crystallised on seeding, m.p. 46-52° C.

後処理

  1. customAn exotherm resulted in the solution
  2. temperaturerefluxing for about 10 minutes
  3. customthe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-123330c67b6b4ba3a55b2d817c1c4a56
出典データセット
uspto-grants-2004_03
特許番号
US06703347B2

関連ノート

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