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Sodium Bicarbonate → (2S,3S)-1-tert-Butoxycarbonyl-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 反応物 | (2S,3S)-3-Amino-1-tert-butoxycarbonyl-2-phenylpiperidine | HCID 11311934 | — |
| 反応物 | 5-(1-Cyanoethyl)-2-methoxybenzaldehyde | HCID 19066487 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (2S,3S)-1-tert-Butoxycarbonyl-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidine | HCID 57028229 | 103.8% |
反応手順
To a stirred and ice-cooled solution of Compound 17 (160 mg, 0.60 mmol) and Compound 14 (120 mg, 0.60 mmol) in dry CH2Cl2 (5 ml) was added NaBH(OAc)3 (430 mg, 2.0 mmol) in one portion. The mixture was stirred at room temperature for 20 hours. The mixture was poured into NaHCO3 aq., and extracted with CH2Cl2. The combined extracts were dried (Na2SO4), and concentrated in vacuo to give Compound 18 as a yellow oil (280 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05789423 |
| 出典データセット | uspto-grants-1998_08 |
| ORD ID | ord-6d9f25a64db247fdb285099b400e9bed |
| 出典メモ | uspto-grants-1998_08 |