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Carbon tetrabromide → 4-(1,1-Dimethyl-3,3-dibromo-2-propenyl)anisole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Carbon tetrabromide | HCID 11205 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | 2-(4-Methoxyphenyl)-2-methylpropanal | HCID 11137689 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(1,1-Dimethyl-3,3-dibromo-2-propenyl)anisole | HCID 19066422 | 45% |
反応手順
To a stirred solution of Compound 45 (3.0 g, 17 mmol) and CBr4 (11 g, 34 mmol) in CH2Cl2 (100 ml) was added PPh3 (18 g, 67 mmol) at r.t., and stirred for 1.5 h. The mixture was quenched by the addition of H2O, and extracted with CH2Cl2. The combined organic layers were washed with brine, dried over MgSO4, filtered, and concentrated. This was purified by SiO2 chromatography to give Compound 53 (2.5 g, 45%) as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05789423 |
| 出典データセット | uspto-grants-1998_08 |
| ORD ID | ord-7fb77abeec4e4e33acaabbbc6f9447a3 |
| 出典メモ | uspto-grants-1998_08 |