(2S,3S)-3-Amino-1-tert-butoxycarbonyl-2-phenylpiperidine → (2S,3S)-1-tert-Butoxycarbonyl-3-[2-Methoxy-5-[1-(1,3-dithiolan-2-yl)-1-methylethyl]benzyl]amino-2-phenylpiperidine

反応式

[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:8]([C:11]([CH:14]2[S:18][CH2:17][CH2:16][S:15]2)([CH3:13])[CH3:12])=[CH:7][C:4]=1[CH:5]=O.[NH2:19][C@H:20]1[CH2:25][CH2:24][CH2:23][N:22]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[C@H:21]1[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1.C(OC(N1CCC[C@H](NCC2C=C(C(C#N)C)C=CC=2OC)[C@@H]1C1C=CC=CC=1)=O)(C)(C)C>>[C:29]([O:28][C:26]([N:22]1[CH2:23][CH2:24][CH2:25][C@H:20]([NH:19][CH2:5][C:4]2[CH:7]=[C:8]([C:11]([CH:14]3[S:18][CH2:17][CH2:16][S:15]3)([CH3:13])[CH3:12])[CH:9]=[CH:10][C:3]=2[O:2][CH3:1])[C@@H:21]1[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:27])([CH3:32])([CH3:30])[CH3:31]