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Triethylamine → N-(2-hydroxy-5-bromophenyl)-3,3-dimethylbutyramide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3,3-Dimethylbutanoyl chloride | HCID 81514 | — |
| 反応物 | 2-Amino-4-Bromophenol | HCID 351840 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | N-(2-hydroxy-5-bromophenyl)-3,3-dimethylbutyramide | HCID 22742126 | 31.5% |
反応手順
A solution of tert-butylacetyl chloride (2.7 g, 0.020 mol) in diethyl ether (20 ml) was added dropwise to a solution of 2-amino-4bromophenol (3.8 g, 0.020 mol) and triethylamine (2.1 g, 0.020 mol) in diethyl ether (160 ml) and the mixture was stirred at room temperature for 3 hours. The mixture was filtered and the filtrate was evaporated in vacuo. Purification by flash column chromatography on silica gel, eluting initially with ethyl acetate:dichloromethane 1.5:98.5 and then with ethyl acetate:dichloromethane 2.5:97.5, gave N-(2-hydroxy-5-bromophenyl)-3,3-dimethylbutyramide (1.8 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06703347B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-a4dae2ba05c94e56acd37a42b6eece85 |
| 出典メモ | uspto-grants-2004_03 |