6-Nitro-1H-indole → 6-Nitro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole
反応式
[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].O.Cl.[NH:15]1[CH2:20][CH2:19][C:18](=O)[CH2:17][CH2:16]1>>[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([C:8]([C:18]3[CH2:19][CH2:20][NH:15][CH2:16][CH:17]=3)=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]参加物
3
実験手順
The title compound was prepared in a fashion similar to that described in Preparation 30 from 6-nitroindole (6.0 g, 37 mmol) and 4-piperidone hydrochloride hydrate (11.4 g, 74 mmol). The product was isolated as an orange solid. Yield 8.8 g (97%). mp 247°-250° C.(dec.) FDMS m/e=243 (M+ of free base).
後処理
- customThe product was isolated as an orange solid
出典と根拠
- ORDレコード
- ord-07a217c0ceda4c50845e8005d9129442
- 出典データセット
- uspto-grants-1998_08
- 特許番号
- US05789402
反応ノート
読み込み中…