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Toluene → 2-Diethylphosphinoylmethyl-1,3-dioxolane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | 3-Bromo-1,2-propanediol | HCID 20827 | — |
| 反応物 | Diethyl (2,2-diethoxyethyl)phosphonate | HCID 82071 | — |
| 触媒 | p-Toluenesulfonic acid | HCID 6101 | — |
| 生成物 | 2-Diethylphosphinoylmethyl-1,3-dioxolane | HCID 21255858 | — |
反応手順
Diethylphosphonoacetaldehyde diethylacetal (VIIa) was condensed with 3-bromo-1,2-propanediol (Va) in the presence of p-toluenesulfonic acid as a catalyst and reflux in toluene to yield 2-diethylphosphinoylmethyl-1,3-dioxolane of formula (IId) as a mixture of cis and trans isomers;
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05789394 |
| 出典データセット | uspto-grants-1998_08 |
| ORD ID | ord-99dba77c6d954ebd9cf80aceca691da4 |
| 出典メモ | uspto-grants-1998_08 |