Adipic Acid → 5-{2-[3-Hydroxy-3-phenyl-2-pyridin-2-yl-1-(pyridin-2-ylamino)propyl]phenylcarbamoyl}pentanoic acid
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([NH:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=1)[CH:9]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1)[CH:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[OH:11].[C:31](O)(=[O:39])[CH2:32][CH2:33][CH2:34][CH2:35][C:36]([OH:38])=[O:37].C1(N=C=NC2CCCCC2)CCCCC1.N1(O)C2C=CC=CC=2N=N1>>[OH:11][CH:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:9]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1)[CH:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1][C:31]([CH2:32][CH2:33][CH2:34][CH2:35][C:36]([OH:38])=[O:37])=[O:39])[NH:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=1参加物
5
実験手順
Prepared from 1.5 g of 3-(2-aminophenyl)-1-phenyl-2-pyridin-2-yl-3-(pyridin-2-ylamino)propan-1-ol, 3.4 g of hexanedioic acid, 1.04 g of dicyclohexylcarbodiimide and 640 mg of benzotriazol-1-ol, analogously to example II f) Product _of molecular weight 524.6 (C31H32N4O4); MS (ESI+): 525 (M+H+): (ESI−): 523 (M−H+)