Allylamine → HCID 178456990、化合物

HRID 481968

反応式

HRID 481968 の反応式
O.CS[C:4]1[NH:9][C:8]2[CH:10]=[CH:11][N:12]=[CH:13][C:7]=2[S:6](=[O:15])(=[O:14])[N:5]=1.[CH2:16]([NH2:19])[CH:17]=[CH2:18]>>[CH2:16]([NH:19][C:4]1[NH:9][C:8]2[CH:10]=[CH:11][N:12]=[CH:13][C:7]=2[S:6](=[O:15])(=[O:14])[N:5]=1)[CH:17]=[CH2:18]

参加物

3

反応物 2

HCID 7853AllylamineHCID 190647513-Methylsulfanyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide monohydrate

生成物 1

HCID 178456990HCID 178456990、化合物

反応条件

温度
120 °C

実験手順

A mixture of 3-methylsulfanyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide monohydrate (0.5 g) and allylamine (4 mL) was heated in a sealed bumb for 4-5 h at 120° C. After cooling, the amine was removed by distillation under reduced pressure. The residue was dissolved in 0.5N NaOH, treated with charcoal, filtered, and the filtrate was adjusted to pH 6 with 1N HCl. The resulting precipitate was collected by filtration, washed with water and dried to give the title compound as a dihydrate (yield: 0.44 g); m.p. 206°-208° C. (Compound 15).

後処理

  1. temperatureAfter cooling
  2. customthe amine was removed by distillation under reduced pressure
  3. dissolutionThe residue was dissolved in 0.5N NaOH
  4. additiontreated with charcoal
  5. filtrationfiltered
  6. filtrationThe resulting precipitate was collected by filtration
  7. washwashed with water
  8. customdried

出典と根拠

ORDレコード
ord-085a166e785e4f3b85065ec9ad85c7db
出典データセット
uspto-grants-1998_08
特許番号
US05792764

関連ノート

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