2-Aminopropanol → HCID 178460116、化合物

HRID 481970

反応式

HRID 481970 の反応式
O.CS[C:4]1[NH:9][C:8]2[CH:10]=[CH:11][N:12]=[CH:13][C:7]=2[S:6](=[O:15])(=[O:14])[N:5]=1.[NH2:16][CH:17]([CH3:20])[CH2:18][OH:19]>C(OCC)C>[OH:19][CH2:18][CH:17]([NH:16][C:4]1[NH:9][C:8]2[CH:10]=[CH:11][N:12]=[CH:13][C:7]=2[S:6](=[O:15])(=[O:14])[N:5]=1)[CH3:20]

参加物

4

反応物 2

HCID 51262-AminopropanolHCID 190647513-Methylsulfanyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide monohydrate

生成物 1

HCID 178460116HCID 178460116、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A suspension of 3-methylsulfanyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide monohydrate and 2-amino-1-propanol (0.75 mL) was refluxed for 90 min (until completion of the reaction; t.l.c.). After cooling, the addition of diethylether (20 mL) gave rise to the separation of an oily residue. After decantation of the etheral solution, the residue was solubilized in methanol (1 mL) and then supplemented with diethylether (15 mL). An oily residue separated again. After decantation of the supernatent, the oily residue was solubilized in acetone (6 mL). A fine precipitate readily appeared. After 3 h at +4° C., the resulting precipitate was collected by filtration, washed with acetone and dried (yield: 0.33 g); m.p. 213°-216° C. (Compound 19).

後処理

  1. temperaturewas refluxed for 90 min (
  2. customuntil completion of the reaction
  3. temperatureAfter cooling
  4. customgave rise
  5. customto the separation of an oily residue
  6. customAn oily residue separated again
  7. filtrationthe resulting precipitate was collected by filtration
  8. washwashed with acetone
  9. customdried (yield: 0.33 g)

出典と根拠

ORDレコード
ord-c0c6d6652c6e44438236c643e2c99a69
出典データセット
uspto-grants-1998_08
特許番号
US05792764

関連ノート

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