化工社化工社 化学情報印刷レポート · 研究参考用
Ethanol → N-(1,2,3,4-tetrahydro-2-propyl-5-isoquinolinyl)-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 1-Iodopropane | HCID 33643 | — |
| 反応物 | 5-Nitroisoquinoline | HCID 69085 | — |
| 生成物 | N-(1,2,3,4-tetrahydro-2-propyl-5-isoquinolinyl)-acetamide | HCID 10376661 | — |
反応手順
A solution of 5-nitroisoquinoline (25 g, 0.144 mol) and iodopropane (36.7 g, 0.216 mol) in 500 mL of EtOH was converted to the title compound by the procedures described in Example 1. The crude title compound was purified by chromatography (silica gel, 95:5 EtOAc:EtOH). The purified product was recrystallized from iPr2O/THF to give the title compound as a white solid (3.33 g, 18%), mp=123° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06703391B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-6b284eb5fb784751a6f68a70a1b7e4ac |
| 出典メモ | uspto-grants-2004_03 |