Ammonium Hydroxide → 8-Bromo-1,2,3,4-tetrahydro-2-methyl-6-nitro-5-isoquinolinamine
反応式
[Br:1][C:2]1[CH:3]=[C:4]([N+:17]([O-:19])=[O:18])[C:5]([NH:13]C(=O)C)=[C:6]2[C:11]=1[CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]2.[NH4+].[OH-]>O>[Br:1][C:2]1[C:11]2[CH2:10][N:9]([CH3:12])[CH2:8][CH2:7][C:6]=2[C:5]([NH2:13])=[C:4]([N+:17]([O-:19])=[O:18])[CH:3]=1参加物
4
実験手順
A solution of the product from Example 7 (3.68 g, 11.2 mmol) and 80 mL of 3:2H2SO4:H2O was heated at 90° C. for 1 hour. The reaction mixture was cooled and poured onto ice, and the resulting solution was made basic with concentrated aqueous NH4OH solution. The solid that formed was collected by suction filtration and dried under vacuum to give the title compound as a yellow solid (3.17 g, 99%).
後処理
- temperatureThe reaction mixture was cooled
- additionpoured onto ice
- customThe solid that formed
- filtrationwas collected by suction filtration
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-cbb1d9bde2784addb419500705adbb72
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06703391B2
反応ノート
読み込み中…