Dimethylacetamide → 2,3,5,6-Tetrafluorobenzoic Acid

HRID 482145

反応式

HRID 482145 の反応式
CN(C)C(=O)C.[F:7][C:8]1[C:16]([F:17])=[C:15](C(O)=O)[C:14]([F:21])=[C:13]([F:22])[C:9]=1[C:10]([OH:12])=[O:11]>O>[F:7][C:8]1[C:16]([F:17])=[CH:15][C:14]([F:21])=[C:13]([F:22])[C:9]=1[C:10]([OH:12])=[O:11]

参加物

4

反応物 2

HCID 31374DimethylacetamideHCID 695492,3,5,6-Tetrafluoroterephthalic acid

生成物 1

HCID 5675332,3,5,6-Tetrafluorobenzoic Acid収率 98%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
20 °C

実験手順

N,N-Dimethylacetamide (14.0 parts) and 2,3,5,6-tetrafluoroterephthalic acid (2.91 parts) was heated at 70° C. for 4 hours before cooling to 20° C. adding water (7 parts) and cooling to 5° C. The precipitated solid was collected by filtration and washed with cold water and dried, the aqueous filtrates were evaporated under vacuum and the resultant solids combined to give 2,3,5,6-tetrafluorobenzoic acid (98%). 1,2,4,5-tetrafluorobenzene (2%) was also formed.

後処理

  1. temperaturecooling to 5° C
  2. filtrationThe precipitated solid was collected by filtration
  3. washwashed with cold water
  4. customdried
  5. customthe aqueous filtrates were evaporated under vacuum

出典と根拠

ORDレコード
ord-c0a4bb5b3740452caefe96c7cf33b70b
出典データセット
uspto-grants-1998_08
特許番号
US05792887

関連ノート

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