Hydrochloric Acid → N-(7-chloro-2,3-dihydro-2-methyl-1H-isoindol-4-yl)acetamide

HRID 48216ノート

反応式

HRID 48216 の反応式
[CH3:1][N:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[NH:11][C:12](=[O:14])[CH3:13])[CH2:3]1.Cl.[Cl:16]([O-])=O.[Na+]>C(O)C>[Cl:16][C:5]1[CH:6]=[CH:7][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[C:9]2[C:4]=1[CH2:3][N:2]([CH3:1])[CH2:10]2

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 22742473HCID 22742473、化合物HCID 23668197Sodium Chlorite

生成物 1

HCID 22742484N-(7-chloro-2,3-dihydro-2-methyl-1H-isoindol-4-yl)acetamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of N-(2,3-dihydro-2-methyl-1H-isoindol-4-yl)acetamide (20 g), hydrochloric acid (37%, 2.5 mL), and sodium chlorite (15%, 10 ml) in 96% ethanol (20 mL) was stirred at room temperature for 4 hours. The solvent was removed by evaporation, whereafter the residue was treated with saturated Na2CO3 in water to pH=7. The precipitated product was filtered off and washed with water and ether. Yield 1.1 g, mp 147-150° C.

後処理

  1. customThe solvent was removed by evaporation, whereafter the residue
  2. additionwas treated with saturated Na2CO3 in water to pH=7
  3. filtrationThe precipitated product was filtered off
  4. washwashed with water and ether

出典と根拠

ORDレコード
ord-fbf0c72f953f40b19e16a5b5052f034b
出典データセット
uspto-grants-2004_03
特許番号
US06703391B2

反応ノート

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