5-Nitroisoquinoline → 5-Aminoisoquinoline

HRID 48219

反応式

HRID 48219 の反応式
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]=[CH:9]2)([O-])=O>CO.[Ni]>[CH:9]1[C:10]2[CH:11]=[CH:12][CH:13]=[C:4]([NH2:1])[C:5]=2[CH:6]=[CH:7][N:8]=1

参加物

4

反応物 1

HCID 690855-Nitroisoquinoline

生成物 1

HCID 707665-Aminoisoquinoline収率 98%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

5-Nitroisoquinoline (100.3 g, 0.576 mol) was dissolved in MeOH and shaken with Raney nickel (10 g) on a Parr apparatus under a H2 atmosphere (50 psi) for 21 hours. The MeOH was removed in vacuo, the residue dissolved in chloroform (150 mL), and filtered into 600 mL petroleum ether. The solid was collected by filtration. This trituration procedure was repeated several times to give 81.24 g (98%) of the desired product.

後処理

  1. customThe MeOH was removed in vacuo
  2. dissolutionthe residue dissolved in chloroform (150 mL)
  3. filtrationfiltered into 600 mL petroleum ether
  4. filtrationThe solid was collected by filtration

出典と根拠

ORDレコード
ord-acd1c103d3db423b8f7a7621644f9507
出典データセット
uspto-grants-2004_03
特許番号
US06703391B2

関連ノート

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