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Water → 4-Chloroisatoic anhydride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Phosgene | HCID 6371 | — |
| 反応物 | Dodecylpyridinium chloride | HCID 7717 | — |
| 反応物 | 2-Amino-4-chlorobenzoic acid | HCID 66646 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-Chloroisatoic anhydride | HCID 329105 | 67% |
反応手順
According to the same manner as in Example 4, except that the flask was changed to 300 ml flask, laurylpyridinium chloride was not used, 103 g of water was added, and that amounts of toluene, phosgene and 4-chloroanthranilic acid were changed to 34 g, 40 g and 35 g, respectively, 35.6 g of 7-chloroisatoic anhydride (purity: 73.8%) was obtained. The yield was 67% and the volume efficiency was 9 g/100 ml.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05795984 |
| 出典データセット | uspto-grants-1998_08 |
| ORD ID | ord-cc6f524ba1f14846bd4f24da62559d0f |
| 出典メモ | uspto-grants-1998_08 |