Dimethylformamide → [(6-Nitro-5-quinolinyl)amino]oxo-acetic acid ethyl ester
反応式
[NH2:1][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.C(N([CH2:20][CH3:21])CC)C.CC[C:24]([C:26](Cl)=[O:27])=[O:25].CN(C)C=[O:32]>>[CH2:20]([O:32][C:24](=[O:25])[C:26]([NH:1][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2)=[O:27])[CH3:21]参加物
5
反応条件
- 温度
- 50 °C
実験手順
A solution of 5-amino-6-nitroquinoline (3 g, 16 mmol) in 50 mL dimethylformamide was treated with triethylamine (3.2 g, 32 mmol) and ethyloxalyl chloride (3.2 g, 24 mmol) and heated at 50° C. for 1 hour. After removing the triethylamine hydrochloride by filtration, the filtrate was concentrated and diethyl ether added. The title compound (3.7 g, 80% yield) was collected by filtration.